The EU–LAC relationship, historically rooted in cooperation and shared values, is being redefined amid global uncertainty, geoeconomic reconfiguration, and trade disputes. With the EU advancing “open strategic autonomy” and LAC positioned as a key supplier for the green transition, both regions face the challenge of aligning strategic interests with developmental goals. The IV EU–CELAC Summit in Santa Marta will be a decisive moment to revitalise this biregional partnership.